Code Name:C441 CAS No.: 2023788-19-2 Version: V1.0 | For Research Use Only
Tirzepatide is a synthetic 39‑amino acid peptide that acts as a dual agonist of the glucose‑dependent insulinotropic polypeptide (GIP) and glucagon‑like peptide‑1 (GLP‑1) receptors. It is the first approved therapy of its kind for type 2 diabetes mellitus and chronic weight management.
The molecule contains two non‑natural amino acids (Aib, α‑aminoisobutyric acid) which enhance proteolytic stability and prolong plasma half‑life. The C‑terminal amidation and a C20 fatty diacid side chain enable strong albumin binding, allowing for once‑weekly administration.
| Product Name | Tirzepatide |
| CAS NO | 2023788-19-2 |
| Formula | C₂₂₅H₃₄₈N₄₈O₆₈ |
| MW | ~4813.5 g/mol |
| Sequence | H-Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Lys-Ala-Gln-Lys-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ |
| Parameter | Specification |
|---|---|
| Appearance | White to off‑white lyophilized powder or solid |
| Purity (by HPLC) | ≥ 99.0% (pharmaceutical grade) |
| Water Content (Karl Fischer) | ≤ 7.0% – 8.0% |
| Related Substances (Impurities) | Total impurities ≤ 1.0% |
| Endotoxins | < 5.0 EU/mg |
| Peptide Content | ≥ 85.0% |
| Residual TFA | < 1.0% |
| Parameter | Value |
|---|---|
| Solubility | Soluble in DMSO, dilute acetic acid, and water (pH 3‑4) |
| Isoelectric Point (pI) | ~5.4 |
| Log P (calculated, pH 7.4) | –1.3 |
| Condition | Stability |
|---|---|
| Powder at –20°C | 3 years |
| Powder at 4°C | 2 years |
| Solution at –80°C | 6 months |
| Solution at –20°C | 1 month |
| Precautions | Protect from light. Avoid repeated freeze‑thaw cycles. |
For research into type 2 diabetes mellitus and obesity.
As an active pharmaceutical ingredient (API) for formulation development.
The above specifications are typical for high‑quality research‑grade material. Actual batch‑specific data (e.g., impurity profile, residual solvents) are provided in the Certificate of Analysis (COA) accompanying each shipment.
Always reconstitute in an appropriate buffer (e.g., sterile water or PBS) immediately before use and store any unused solution at –80°C for short‑term use.
Disclaimer: This TDS is compiled from publicly available information and standard industry practice. It is for informational purposes only and does not constitute a guarantee of any particular batch. Always refer to the actual COA and quality documentation provided by the supplier for the specific material you receive.
Copyrights © 2026 All Rights Reserved by Vitaco