Selank

Selank

Selank Raw Material

Product Name: Selank Raw Material

CAS No.: 129954-34-3

Document Version: V1.0

Application: For Laboratory Research Only

Date: 2026


1. Basic Chemical Information

ItemSpecification
Full NameSelank
SynonymTuftsin analog; Selank peptide
Molecular FormulaC33H57N11O9
Molecular Weight747.88 Da (free base)
1-Letter SequenceThr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂
3-Letter SequenceH-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂
Peptide StructureLinear heptapeptide, C-terminal amidated
Biological FunctionTuftsin derivative; modulates immune function, regulates neurotransmitters, anxiolytic research, neuroimmunology studies

2. Physical Characteristics

  • Appearance: White to off-white lyophilized powder
  • Odor: Odorless
  • Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.5–8.0); soluble in DMSO; insoluble in non-polar organic solvents
  • pH (1 mg/mL aqueous solution): 6.0 – 8.0
  • Hygroscopicity: Moderately hygroscopic; avoid long exposure to air and high humidity

3. Quality Specification

Test ItemTest MethodSpecification
IdentityRP-HPLC, ESI-MSConsistent with reference standard; Measured MW ±2 Da
Chromatographic Purity (RP-HPLC, Area %)RP-HPLC≥99.0%
Largest Single Unknown ImpurityRP-HPLC≤0.50%
Total Related ImpuritiesRP-HPLC≤2.0%
Peptide Assay ContentHPLC Quantitation / Potentiometric Titration98.0% ~ 102.0%
Water ContentKarl Fischer Titration≤1.0%
Residual TFA / AcetateIon Chromatography≤0.5%
Endotoxin (LAL, USP <85>)Turbidimetric LAL Method≤10 EU/mg
Heavy Metals (Pb, As, Cd, Hg)ICP-MSEach ≤10 ppm
Residual Organic SolventsGCComply with ICH Q3C requirements
Amino Acid Composition AnalysisAmino Acid AnalyzerWithin ±10% theoretical stoichiometry

4. Storage & Stability

Lyophilized Solid Powder

  • Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
  • Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
  • Important: Avoid repeated freeze-thaw cycles

Reconstituted Aqueous Stock Solution

  • -80 ℃: Stable up to 6 months
  • -20 ℃: Stable up to 1 month
  • Do not store aqueous solution at 4 ℃ or room temperature for extended periods

5. Stock Solution Preparation Guidance

Molecular Weight = 747.88

  • 1 mM solution: 0.748 mg Selank per 1 mL solvent
  • Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer

    Suggestion: Prepare fresh working solution for in vivo experiments.

6. Safety & Handling Notes

  • This synthetic peptide may irritate skin, eyes and respiratory tract.
  • Required PPE: Lab coat, nitrile gloves, safety goggles.
  • Prevent inhalation of powder dust and direct skin contact.
  • Waste shall be disposed as chemical waste following local regulations.
  • Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.

7. RP-HPLC Analytical Conditions

  • Column: C18 analytical column (250×4.6 mm, 5 μm)
  • Mobile Phase A: 0.1% TFA in Water
  • Mobile Phase B: 0.1% TFA in Acetonitrile
  • Detection wavelength: 220 nm / 280 nm
  • Flow rate: 1.0 mL/min
  • Column temperature: 30 ℃

**End of Document**

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