Selank Raw Material
Product Name: Selank Raw Material
CAS No.: 129954-34-3
Document Version: V1.0
Application: For Laboratory Research Only
Date: 2026
1. Basic Chemical Information
| Item | Specification |
|---|
| Full Name | Selank |
| Synonym | Tuftsin analog; Selank peptide |
| Molecular Formula | C33H57N11O9 |
| Molecular Weight | 747.88 Da (free base) |
| 1-Letter Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ |
| 3-Letter Sequence | H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ |
| Peptide Structure | Linear heptapeptide, C-terminal amidated |
| Biological Function | Tuftsin derivative; modulates immune function, regulates neurotransmitters, anxiolytic research, neuroimmunology studies |
2. Physical Characteristics
- Appearance: White to off-white lyophilized powder
- Odor: Odorless
- Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.5–8.0); soluble in DMSO; insoluble in non-polar organic solvents
- pH (1 mg/mL aqueous solution): 6.0 – 8.0
- Hygroscopicity: Moderately hygroscopic; avoid long exposure to air and high humidity
3. Quality Specification
| Test Item | Test Method | Specification |
|---|
| Identity | RP-HPLC, ESI-MS | Consistent with reference standard; Measured MW ±2 Da |
| Chromatographic Purity (RP-HPLC, Area %) | RP-HPLC | ≥99.0% |
| Largest Single Unknown Impurity | RP-HPLC | ≤0.50% |
| Total Related Impurities | RP-HPLC | ≤2.0% |
| Peptide Assay Content | HPLC Quantitation / Potentiometric Titration | 98.0% ~ 102.0% |
| Water Content | Karl Fischer Titration | ≤1.0% |
| Residual TFA / Acetate | Ion Chromatography | ≤0.5% |
| Endotoxin (LAL, USP <85>) | Turbidimetric LAL Method | ≤10 EU/mg |
| Heavy Metals (Pb, As, Cd, Hg) | ICP-MS | Each ≤10 ppm |
| Residual Organic Solvents | GC | Comply with ICH Q3C requirements |
| Amino Acid Composition Analysis | Amino Acid Analyzer | Within ±10% theoretical stoichiometry |
4. Storage & Stability
Lyophilized Solid Powder
- Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
- Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
- Important: Avoid repeated freeze-thaw cycles
Reconstituted Aqueous Stock Solution
- -80 ℃: Stable up to 6 months
- -20 ℃: Stable up to 1 month
- Do not store aqueous solution at 4 ℃ or room temperature for extended periods
5. Stock Solution Preparation Guidance
Molecular Weight = 747.88
- 1 mM solution: 0.748 mg Selank per 1 mL solvent
- Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer
Suggestion: Prepare fresh working solution for in vivo experiments.
6. Safety & Handling Notes
- This synthetic peptide may irritate skin, eyes and respiratory tract.
- Required PPE: Lab coat, nitrile gloves, safety goggles.
- Prevent inhalation of powder dust and direct skin contact.
- Waste shall be disposed as chemical waste following local regulations.
- Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.
7. RP-HPLC Analytical Conditions
- Column: C18 analytical column (250×4.6 mm, 5 μm)
- Mobile Phase A: 0.1% TFA in Water
- Mobile Phase B: 0.1% TFA in Acetonitrile
- Detection wavelength: 220 nm / 280 nm
- Flow rate: 1.0 mL/min
- Column temperature: 30 ℃
**End of Document**