BPC-157 Raw Material Technical Data Sheet
Product Name: BPC-157 Raw Material
CAS No.: 137525-51-0
Document Version: V1.0
Application: For Laboratory Research Only
Date: 2026
1. Basic Chemical Information
| Item | Specification |
|---|
| Full Name | BPC-157 (Body Protection Compound 157, Pentadecapeptide) |
| Synonym | BPA |
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.54 Da (free base) |
| 1-Letter Sequence | GEPPPGKPADDAGLV |
| 3-Letter Sequence | H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH |
| Peptide Length | 15 amino acids, linear synthetic pentadecapeptide |
| Biological Function | Promotes angiogenesis, cell migration, tissue regeneration, gastrointestinal mucosal protection, tendon & ligament repair, anti-inflammatory effect |
2. Physical Characteristics
- Appearance: White to off-white lyophilized powder
- Odor: Odorless
- Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.5–8.0); sparingly soluble in DMSO; insoluble in non-polar organic solvents
- pH (1 mg/mL aqueous solution): 6.0 – 8.0
- Hygroscopicity: Moderately hygroscopic; avoid long exposure to air and high humidity
3. Quality Specification
| Test Item | Test Method | Specification |
|---|
| Identity | RP-HPLC, ESI-MS | Consistent with reference standard; Measured MW ±2 Da |
| Chromatographic Purity (RP-HPLC, Area %) | RP-HPLC | ≥99.0% |
| Largest Single Unknown Impurity | RP-HPLC | ≤0.50% |
| Total Related Impurities | RP-HPLC | ≤2.0% |
| Peptide Assay Content | HPLC Quantitation / Potentiometric Titration | 98.0% ~ 102.0% |
| Water Content | Karl Fischer Titration | ≤1.0% |
| Residual TFA / Acetate | Ion Chromatography | ≤0.5% |
| Endotoxin (LAL, USP <85>) | Turbidimetric LAL Method | ≤10EU/mg |
| Heavy Metals (Pb, As, Cd, Hg) | ICP-MS | Each ≤10 ppm |
| Residual Organic Solvents | GC | Comply with ICH Q3C requirements |
| Amino Acid Composition Analysis | Amino Acid Analyzer | Within ±10% theoretical stoichiometry |
4. Storage & Stability
Lyophilized Solid Powder
- Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
- Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
- Important: Avoid repeated freeze-thaw cycles
Reconstituted Aqueous Stock Solution
- -80 ℃: Stable up to 6 months
- -20 ℃: Stable up to 1 month
- Do not store aqueous solution at 4 ℃ or room temperature for extended periods
5. Stock Solution Preparation Guidance
Molecular Weight = 1419.54
- 1 mM solution: 1.420 mg BPC-157 per 1 mL solvent
- Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer
Suggestion: Prepare fresh working solution for in vivo experiments.
6. Safety & Handling Notes
- This synthetic peptide may irritate skin, eyes and respiratory tract.
- Required PPE: Lab coat, nitrile gloves, safety goggles.
- Prevent inhalation of powder dust and direct skin contact.
- Waste shall be disposed as chemical waste following local regulations.
- Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.
7. RP-HPLC Analytical Conditions
- Column: C18 analytical column (250×4.6 mm, 5 μm)
- Mobile Phase A: 0.1% TFA in Water
- Mobile Phase B: 0.1% TFA in Acetonitrile
- Detection wavelength: 220 nm / 280 nm
- Flow rate: 1.0 mL/min
- Column temperature: 30 ℃
**End of Document**