KPV

Product Name: KPV Raw Material

CAS No.: 67727-97-3

Synonym: α-MSH (11-13), Lys-Pro-Val, H-Lys-Pro-Val-OH

Document Version: V1.0

Application: For Laboratory Research Only

Date: 2026

1. Basic Chemical Information

2. Physical Characteristics

• Appearance: White to off-white lyophilized powder
• Odor: Odorless
• Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.0–8.0); soluble in DMSO; insoluble in non-polar organic solvents
• pH (1 mg/mL aqueous solution): 6.0 – 8.0
• Hygroscopicity: Moderately hygroscopic; avoid long exposure to air, moisture

3. Quality Specification

4. Storage & Stability

Lyophilized Solid Powder

• Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
• Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
• Important: Avoid repeated freeze-thaw cycles

Reconstituted Aqueous Stock Solution

• -80 ℃: Stable up to 6 months
• -20 ℃: Stable up to 1 month
• Do not store aqueous solution at 4 ℃ or room temperature for extended periods

5. Stock Solution Preparation Guidance

Molecular Weight = 342.43 Da

• 1 mM solution: 0.342 mg KPV per 1 mL solvent
• Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer
  

  Suggestion: Prepare fresh working solution for in vitro & in vivo experiments.

6. Safety & Handling Notes

• This synthetic tripeptide may irritate skin, eyes and respiratory tract.
• Required PPE: Lab coat, nitrile gloves, safety goggles.
• Prevent inhalation of powder dust and direct skin contact.
• Waste shall be disposed as chemical waste following local regulations.
• Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.

7. RP-HPLC Analytical Conditions

• Column: C18 analytical column (250×4.6 mm, 5 μm)
• Mobile Phase A: 0.1% TFA in Water
• Mobile Phase B: 0.1% TFA in Acetonitrile
• Detection wavelength: 220 nm / 280 nm
• Flow rate: 1.0 mL/min
• Column temperature: 30 ℃

8. Analytical Spectrum Characterization

8.1 RP-HPLC Chromatogram

Sharp symmetric main peak; impurity peaks comply with specification. Representative batch HPLC chromatogram available upon request.

8.2 NMR Spectroscopy (¹H-NMR / ¹³C-NMR)

Solvent: D₂O / DMSO‑d₆; 400/500 MHz. Characteristic signals of Lys, Pro, Val residues match target structure. Full NMR spectrum available on formal inquiry.

8.3 ESI-MS Identity Confirmation

Theoretical MW:342.43 Da; Expected ion: [M+H]⁺=343.43, mass tolerance ±2 Da.

**End of Document**