Tesamorelin Acetate Raw Material

Product Name: Tesamorelin Acetate Raw Material

CAS No.: 901758-09-6

Synonym: TH9507, Egrifta, trans-3-hexenoyl-GHRH(1-44)-NH₂ acetate salt

Document Version: V1.0

Application: For Laboratory Research Only

Date: 2026

1. Basic Chemical Information

Item	Specification
Full Name	Tesamorelin Acetate
Chemical Name	(3E)-Hex-3-enoylsomatoliberin (human) acetate
Molecular Formula	C223H370N72O69S
Molecular Weight	5135.89 Da (free base)；5195.88 Da (acetate salt)
1-Letter Sequence	trans-3-hexenoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH₂
Peptide Feature	44 amino acids modified GHRH analog, N-terminal trans-3-hexenoyl lipidation, C-terminal amidated
Target Receptor	GHRH Receptor (Growth Hormone-Releasing Hormone Receptor)
Biological Function	Long-acting GHRH agonist, stimulates endogenous growth hormone secretion, regulates GH/IGF-1 axis, metabolism, visceral fat and endocrine research

Appearance: White to off-white lyophilized powder
Odor: Odorless
Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.5–8.0); soluble in DMSO; insoluble in non-polar organic solvents
pH (1 mg/mL aqueous solution): 6.0 – 8.0
Hygroscopicity: Moderately hygroscopic; avoid long exposure to air and high humidity

Test Item	Test Method	Specification
Identity	RP-HPLC, ESI-MS	Consistent with reference standard; Measured MW ±2 Da
Chromatographic Purity (RP-HPLC, Area %)	RP-HPLC	≥98.0% (Typical ≥99.0%)
Largest Single Unknown Impurity	RP-HPLC	≤0.50%
Total Related Impurities	RP-HPLC	≤2.0%
Peptide Assay Content	HPLC Quantitation / Potentiometric Titration	98.0% ~ 102.0%
Water Content	Karl Fischer Titration	≤1.0%
Residual TFA / Acetate	Ion Chromatography	≤0.5%
Endotoxin (LAL, USP <85>)	Turbidimetric LAL Method	≤100 EU/mg
Heavy Metals (Pb, As, Cd, Hg)	ICP-MS	Each ≤10 ppm
Residual Organic Solvents	GC	Comply with ICH Q3C requirements
Amino Acid Composition Analysis	Amino Acid Analyzer	Within ±10% theoretical stoichiometry

Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
Important: Avoid repeated freeze-thaw cycles

-80 ℃: Stable up to 6 months
-20 ℃: Stable up to 1 month
Do not store aqueous solution at 4 ℃ or room temperature for extended periods

Molecular Weight (Free Base)= 5135.89 Da

1 mM solution: 5.136 mg Tesamorelin per 1 mL solvent
Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer
Suggestion: Gentle dissolution; prepare fresh working solution for in vivo experiments to preserve bioactivity.

This synthetic long-chain peptide may irritate skin, eyes and respiratory tract.
Required PPE: Lab coat, nitrile gloves, safety goggles.
Prevent inhalation of powder dust and direct skin contact.
Waste shall be disposed as chemical waste following local regulations.
Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.

**End of Document**