Orforglipron
Product Name: Orforglipron
CAS No.: 2212020-52-3
Synonym: LY3502970, GLP-1 Receptor Agonist 1, Orally Active GLP-1 Agonist
Document Version: V1.0
Application Scope: For Laboratory Research Only
Release Date: 2026
1. Basic Chemical Information
Test Item | Specification |
|---|
Full Name | Orforglipron |
Chemical Name | Orforglipron (LY3502970) |
Molecular Formula | C₄₈H₄₈F₂N₁₀O₅ |
Molecular Weight | 882.97 Da |
Chemical Structure | Small-molecule synthetic compound, oral bioavailable GLP-1 receptor agonist |
Target | GLP-1 Receptor (Glucagon-Like Peptide-1 Receptor) |
Biological Function | Orforglipron (LY3502970) is a potent, orally active non-peptide GLP-1 receptor agonist. It activates GLP-1 signaling, improves glucose metabolism, reduces appetite, regulates lipid metabolism, and is widely used in diabetes mellitus, metabolic disorder and weight management mechanism research. |
2. Physical Characteristics
Appearance: White to off-white crystalline powder
Odor: Odorless
Solubility: Highly soluble in DMSO and DMF; sparingly soluble in methanol and ethanol; slightly soluble in water; insoluble in non-polar organic solvents
Solubility Data: ≥100 mg/mL in DMSO (ultrasonic assisted dissolution <60℃)
Hygroscopicity: Slightly hygroscopic. Keep sealed, dry and dark storage environment
XLogP: 7.77 (High lipophilicity)
3. Quality Specifications
Test Item | Test Method | Standard Specification |
|---|
Identity | RP-HPLC, ESI-MS | Match with standard reference; MW tolerance ±2 Da |
Purity (HPLC Area) | RP-HPLC | ≥98.0% (Typical ≥99.0%) |
Maximum Single Impurity | RP-HPLC | ≤0.50% |
Total Impurities | RP-HPLC | ≤2.0% |
Compound Assay Content | HPLC / Titration | 98.0% – 102.0% |
Water Content | Karl Fischer | ≤1.0% |
Residual Organic Solvents | GC | Compliant with ICH Q3C standard |
Endotoxin | LAL Test (USP <85>) | ≤100 EU/mg |
Heavy Metals | ICP-MS | Pb,As,Cd,Hg ≤10 ppm each |
4. Storage & Stability Conditions
4.1 Solid Powder
Long-term Storage: ≤ -80℃, sealed, dry and dark environment, shelf life: 24 months
Medium-term Storage: -20℃, sealed and desiccated, shelf life: 12 months
Note: Avoid repeated freezing and thawing cycles, prevent moisture and light degradation
4.2 Reconstituted Solution
5. Stock Solution Preparation
Molecular Weight: 882.97 Da
1 mM Standard Solution: Weigh 0.883 mg Orforglipron powder, dissolve in 1 mL DMSO
Recommended Solvent: DMSO (preferred), DMF, methanol
Operation Tip: Ultrasonic dissolution below 60℃ is recommended for full solubility; prepare fresh solution for cell and pharmacological experiments.
6. Safety Handling & Disclaimer
This synthetic small-molecule compound is slightly irritant to eyes, skin and respiratory tract.
Wear standard PPE: lab coat, nitrile gloves, safety goggles during operation.
Avoid inhalation of dust and direct skin/mucosa contact.
Waste materials shall be disposed in accordance with local chemical waste management regulations.
Strict Disclaimer: This product is only for scientific laboratory research. Not for human clinical use, medication or veterinary application.
7. HPLC Analytical Test Conditions
Column: C18 Analytical Column (250×4.6mm, 5μm)
Mobile Phase A: 0.1% TFA in Water
Mobile Phase B: 0.1% TFA in Acetonitrile
Detection Wavelength: 220 nm / 254 nm / 280 nm
Flow Rate: 1.0 mL/min
Column Temperature: 30℃
8. Analytical Spectrum Characterization
8.1 RP-HPLC Chromatogram
Sharp and symmetric main peak with low impurity content, fully meets research-grade purity standards. Batch-specific HPLC chromatogram is available upon customer request.
8.2 NMR Spectroscopy (¹H-NMR / ¹³C-NMR)
Test solvent: DMSO-d₆, 400–500 MHz. Characteristic chemical shifts match the fluorine-containing heterocyclic structure of Orforglipron, confirming complete structural consistency.
8.3 ESI-MS Identity Confirmation
Theoretical molecular weight: 882.97 Da; Expected quasi-molecular ion [M+H]⁺ = 883.97 Da, mass detection tolerance ±2 Da, meets identity confirmation standard.
End of Document
