Bremelanotide Acetate

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Bremelanotide Acetate Raw Material

Product Name: Bremelanotide Acetate Raw Material

Synonym: PT-141 Acetate

CAS No.: 1607799-13-2

Document Version: V1.0

Application: For Laboratory Research Only

Date: 2026

1. Basic Chemical Information

Item	Specification
Full Name	Bremelanotide Acetate (PT-141 Acetate)
Chemical Name	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH Acetate
Molecular Formula	C52H72N14O12
Molecular Weight	1085.22 Da (acetate salt)
Free Base MW	1025.18 Da
1-Letter Sequence	Ac-Nle-c[DHFRWK]
3-Letter Sequence	Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys, Lactam bridge between Asp & Lys side chain
Peptide Structure	Cyclic heptapeptide, lactam-bridged cyclic peptide
Biological Function	Melanocortin receptor agonist (MC3R / MC4R), research for sexual desire disorder, central nervous system study

2. Physical Characteristics

Appearance: White to off-white lyophilized powder
Odor: Odorless
Solubility: Freely soluble in sterile purified water / neutral PBS (pH 6.5–8.0); soluble in DMSO; insoluble in non-polar organic solvents
pH (1 mg/mL aqueous solution): 6.0 – 8.0
Hygroscopicity: Moderately hygroscopic; avoid long exposure to air and high humidity

3. Quality Specification (Research Grade Raw Material)

Test Item	Test Method	Specification
Identity	RP-HPLC, ESI-MS	Consistent with reference standard; Measured MW ±2 Da
Chromatographic Purity (RP-HPLC, Area %)	RP-HPLC	≥99.0%
Largest Single Unknown Impurity	RP-HPLC	≤0.50%
Total Related Impurities	RP-HPLC	≤2.0%
Peptide Assay Content	HPLC Quantitation / Potentiometric Titration	98.0% ~ 102.0%
Water Content	Karl Fischer Titration	≤1.0%
Residual TFA / Acetate	Ion Chromatography	≤0.5%
Endotoxin (LAL, USP <85>)	Turbidimetric LAL Method	≤10 EU/mg
Heavy Metals (Pb, As, Cd, Hg)	ICP-MS	Each ≤10 ppm
Residual Organic Solvents	GC	Comply with ICH Q3C requirements
Amino Acid Composition Analysis	Amino Acid Analyzer	Within ±10% theoretical stoichiometry

4. Storage & Stability

Lyophilized Solid Powder

Long-term storage: ≤ -80 ℃, sealed, dry, protected from light — Shelf life: 24 months
Medium-term storage: -20 ℃, sealed & desiccated — Shelf life: 12 months
Important: Avoid repeated freeze-thaw cycles

Reconstituted Aqueous Stock Solution

-80 ℃: Stable up to 6 months
-20 ℃: Stable up to 1 month
Do not store aqueous solution at 4 ℃ or room temperature for extended periods

5. Stock Solution Preparation Guidance

Molecular Weight = 1085.22

1 mM solution: 1.085 mg Bremelanotide Acetate per 1 mL solvent
Recommended solvent: Sterile purified water or pH7.0–7.4 PBS buffer
Suggestion: Prepare fresh working solution for in vivo experiments.

6. Safety & Handling Notes

This synthetic peptide may irritate skin, eyes and respiratory tract.
Required PPE: Lab coat, nitrile gloves, safety goggles.
Prevent inhalation of powder dust and direct skin contact.
Waste shall be disposed as chemical waste following local regulations.
Disclaimer: THIS MATERIAL IS FOR LABORATORY RESEARCH ONLY. Not approved for human administration, clinical use or veterinary medication.

7. RP-HPLC Analytical Conditions

Column: C18 analytical column (250×4.6 mm, 5 μm)
Mobile Phase A: 0.1% TFA in Water
Mobile Phase B: 0.1% TFA in Acetonitrile
Detection wavelength: 220 nm / 280 nm
Flow rate: 1.0 mL/min
Column temperature: 30 ℃

**End of Document**

📄 JTX-BPT20260713-COA.pdf 📄 PT-141-HPLC.pdf

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