MOTS-C Raw Material Technical Data Sheet
Product Name: MOTS-C Raw Material
CAS No.: 1627580-64-6
Document Version: V1.0
Application Scope: For Laboratory Research Only
Release Date: 2026
1. Basic Chemical Information
Test Item | Specification |
|---|
Full Name | MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) |
Synonym | Mitochondrial-Derived Peptide, MOTS-C |
Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
Molecular Weight | 2174.59 Da (free base) |
Amino Acid Sequence (1-Letter) | MRWQEMGYIFYPRKLR |
Amino Acid Sequence (3-Letter) | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
Peptide Length | 16 Amino Acids, Linear Synthetic Peptide |
Biological Mechanism | AMPK activator, regulates mitochondrial metabolism and insulin sensitivity |
In Vivo Plasma Half-Life | 30 min – 2 hours |
2. Physical Characteristics
Appearance: White to off-white lyophilized powder
Odor: Odorless
Solubility: Highly soluble in sterile purified water (≥100 mg/mL); soluble in pH 6.0-8.0 phosphate buffer; sparingly soluble in DMSO; insoluble in non-polar organic solvents
Aqueous Solution pH (1 mg/mL): 6.5 – 8.0
Hygroscopicity: Moderately hygroscopic. Long-term exposure to air and high humidity is prohibited.
3. Quality Specifications
Test Item | Test Method | Standard Specification |
|---|
Identity | RP-HPLC, ESI-MS | Match with standard reference; MW tolerance ±2 Da |
Purity (HPLC Area) | RP-HPLC | ≥98.0% (Typical ≥99.0%) |
Maximum Single Impurity | RP-HPLC | ≤0.50% |
Total Impurities | RP-HPLC | ≤2.0% |
Peptide Assay Content | HPLC / Titration | 98.0% – 102.0% |
Water Content | Karl Fischer | ≤1.0% |
Residual TFA/Acetate | Ion Chromatography | ≤0.5% |
Endotoxin | LAL Test (USP <85>) | ≤100 EU/mg |
Heavy Metals | ICP-MS | Pb,As,Cd,Hg ≤10 ppm each |
Residual Organic Solvents | GC | Compliant with ICH Q3C standard |
Amino Acid Composition | Amino Acid Analyzer | Within ±10% theoretical value |
4. Storage & Stability Conditions
4.1 Lyophilized Powder (Original Package)
Long-term Storage: ≤ -80℃, sealed, dry and dark environment, shelf life: 24 months
Medium-term Storage: -20℃, sealed and desiccated, shelf life: 12 months
Note: Avoid repeated freezing and thawing cycles
4.2 Reconstituted Aqueous Solution
5. Stock Solution Preparation
Molecular Weight: 2174.59 Da
1 mM Standard Solution: Weigh 2.175 mg MOTS-C powder, dissolve in 1 mL sterile solvent
Recommended Solvent: Sterile purified water / pH 7.0-7.4 PBS buffer
Operation Tip: Fresh preparation is recommended for in vivo experiments to ensure activity.
6. Safety Handling & Disclaimer
This product is a synthetic peptide chemical, irritant to eyes, skin and respiratory tract.
Wear standard PPE: lab coat, nitrile gloves, safety goggles during operation.
Avoid inhalation of powder dust and direct skin contact.
Waste materials shall be disposed in accordance with local chemical waste regulations.
Strict Disclaimer: This product is only for scientific laboratory research. Not for human clinical use, medication or veterinary application.
7. HPLC Analytical Test Conditions
Column: C18 Analytical Column (250×4.6mm, 5μm)
Mobile Phase A: 0.1% TFA in Water
Mobile Phase B: 0.1% TFA in Acetonitrile
Detection Wavelength: 220 nm / 280 nm
Flow Rate: 1.0 mL/min
Column Temperature: 30℃
End of Document
